Concept


There was obvious interest in applying Mendel's laws to agriculture. Mendel's ideas were also embraced by the eugenics movement, the goal of which was to improve the human species by better breeding. Eugenicists encouraged marriages between people of "good" genetic stock, and discouraged reproduction of the "genetically unfit." Eugenicists wrongly used simple dominant/ recessive schemes to explain complex behaviors and mental illnesses — which we now know involve many genes. They also failed to account for environmental effects on human development. In the United States, restrictive eugenics legislation reflected political and social prejudices, rather than genetic facts. The eugenic description of human life was finally discredited by the horrible consequences of the Nazi quest for racial purity.

Animation


I'm Charles Davenport. I was the director of the Station for Experimental Evolution at Cold Spring Harbor, and I established the Eugenics Record Office (ERO) in 1910. At the ERO, we trained field workers in the collection of data to track human genes. We thought that all human traits, even behavior, were defined by Mendelian inheritance of genes. World War I showed us that a great modern war required drafting thousands of nonmilitary men to take on the rank of naval officer. I offered my 1919 monogragh, Naval Officers: Their Heredity and Development as "an improved method of testing the fitness of untried officers." Naturally, I included Admiral David Farragut among my survey of the traits and pedigrees of 68 famous naval officers. Who isn't familiar with his famous 1864 adage: "Damn the torpedoes! Full speed ahead." He said this while roped to the mast of his flagship, the Hartford. Farragut directed a course straight though an extensive mine field blocking the Union fleet's approach into Mobile bay. I concluded that, like other officers who were "fighters," Farragut's "combative gift" arose from a nervous hyperactivity. His juvenile promise showed up as a love of the sea and adventure. Let me show you his pedigree and tell you about a few of his close relatives. Farragut is highlighted–the filled square is the symbol for a high-ranking naval officer. Notice his father and brother were junior officers, indicated by half-filled squares. Notice also a familial trait for fearlessness. (Marked by a dot.) Father George was master of a gunboat on the Mississippi River during the early 19th century, serving in the war of 1812 and with Gen. Andrew Jackson in the Indian wars in Florida. His "most daring enterprise" was sailing a canoe from New Orleans to Havana. Farragut's mother, Elizabeth, once single-handedly fended off a raiding party of Indians with an axe. Brother William was a junior officer in the navy, and joined David in a cruise against the pirates of the West Indies. Brother George's naval potential was cut short, when he fell off a boat and drowned at age 10. As a teenager, Farragut's only son, Loyall, joined him on his campaign in Florida during the Civil War. He showed the family trait of fearlessness when he insisted on staying on deck as the Hartford passed heavy fire from the Confederate batteries at Port Hudson. From my study, I concluded that thalassophilia, "the love of the sea," is a key trait shared by naval officers. Since it showed itself exclusively in men, I concluded thalassophilia was an X-linked recessive trait. I suppose this sex bias could also be explained by the fact that, in my time, women were only allowed on ships as passengers. I suppose it is also possible that many men in my study might have loved the sea because they grew up around boats and sea-faring men. Farragut himself probably benefitted from being adopted as a child by Naval Commander, David Porter.

Gallery


Charles Davenport, first director of the Eugenics Record Office, 1932.
Charles Davenport at work, around 1933.
Eugenics exhibits were common in the early 1900's. Booths would be set up at local fairs and ERO field workers used the opportunity to collect data. This booth was set up at the Kansas State Free Fair in 1920.
The ERO sponsored "fitter family" contests to promote the idea of "breeding" better humans.
The eugneics tree, used as a logo by the ERO.
(P. 1 of 4) Issue #1 of the Eugenical News, January 1916, the newsletter issued by the Eugenics Record Office.
(P. 2 of 4) Issue #1 of the Eugenical News, January 1916, the newsletter issued by the Eugenics Record Office.
(P. 3 of 4) Issue #1 of the Eugenical News, January 1916, the newsletter issued by the Eugenics Record Office.

Audio/Video


Audio Glossary

Dominant, Inherited, Mendelian inheritance, Pedigree, Recessive

Video Interviews

Garland Allen

Garland Allen is a Professor in the Evolutionary and Population Biology Program at Washington University in St. Louis. He authored Thomas Hunt Morgan: The Man & His Science, and several texts, including Matter, Energy and Life and The Study of Biology.

Clip 1 (1:05)
The beginnings of the American Eugenics movement: the first Eugenics committee.

Clip 2 (0:30)
Applying genetics to humans.

Clip 3 (0:46)
The flaws of Eugenics.

Clip 4 (0:53)
Did any good come out of the Eugenics program?

Biography


 

Charles Davenport was one of the leaders of the eugenics movement. He tried to shape human evolution by applying Mendel's laws to "build" better human stocks.

CHARLES BENEDICT DAVENPORT (1866-1944)

Charles Davenport was one of the most prominent biologists of his time. He was born in Stamford, Connecticut, and went to Harvard University for his education. For a while, he was a professor at the University of Chicago.

In 1890, Davenport became the director of the Biological Laboratory established by the Brooklyn Institute of Arts and Sciences at Cold Spring Harbor. When the Carnegie Institute began looking for a place to set up a research center on evolution, Davenport convinced them that Cold Spring Harbor on Long Island, New York was the ideal locale. The Station for Experimental Evolution opened in 1904 with Davenport as its director. In 1910, with financial backing from the wife of E. H. Harriman, the railroad tycoon, Davenport established the Eugenics Records Office (ERO) at Cold Spring Harbor. Davenport believed that "the general program of the eugenicist is clear - it is to improve the race by inducing young people to make a more reasonable selection of marriage mates; to fall in love intelligently. It also includes the control by the state of the propagation of the mentally incompetent."

During the next 11 years, the ERO trained men and women on the "science" of eugenics and data collection. These field workers helped accumulate a large number of records on "inherited" human traits. The ERO published its results as bulletins, and had its own newsletter. Davenport and the eugenics movement influenced state laws on sterilization, immigration and miscegenation (mixed race marriages). In 1921, the ERO merged with the Station for Experimental Evolution to become the Department of Genetics. Davenport continued to be a director until 1934.

Factoid

Links


 

Links

Cold Spring Harbor Laboratory

This site has a short history on the development of the current research facilities from the Biological Laboratories and the Station for Experimental Evolution.

The Center for Bioethics

The University of Pennslyvania has an web site where articles and comments on bioethical subjects are posted.

National Human Genome Research Institute (NHGRI)

NHGRI was established in 1989 to head the Human Genome Project for the National Institute of Health. NHGRI runs the Ethical, Legal and Social Implications program (ELSI) to deal with issues from the mapping and sequencing of the human genome.

Bibliography

  • Davenport, Charles Benedict, 1919, Naval Officers, Their Heredity and Development, Carnegie Institution of Washington.

  • Rushton, Alan R., 1994, Genetics and Medicine in the United States 1800 to 1922, Johns Hopkins University Press, Baltimore.

  • Snyder, Laurence H., 1946, Charles Benedict Davenport: a Biography, Genetics, 31: frontpiece, Genetics Society of America.

Glossary


Dominant - A gene that almost always results in a specific physical characteristic, for example, a disease, even though the patient's genome possesses only one copy. With a dominant gene, the chance of passing on the gene (and therefore the disease) to children is 50-50 in each pregnancy.
Inherited - Transmitted through genes from parents to offspring.
Mendelian inheritance -
Pedigree - A simplified diagram of a family's genealogy that shows family members' relationships to each other and how a particular trait or disease has been inherited.
Recessive - A genetic disorder that appears only in patients who have received two copies of a mutant gene, one from each parent.

Children resemble their parents.
Genes come in pairs.
Genes don't blend.
Some genes are dominant.
Genetic inheritance follows rules.
Genes are real things.
All cells arise from pre-existing cells.
Sex cells have one set of chromosomes; body cells have two.
Specialized chromosomes determine gender.
Chromosomes carry genes.
Genes get shuffled when chromosomes exchange pieces.
Evolution begins with the inheritance of gene variation.
Mendelian laws apply to human beings.
DNA and proteins are the molecules of the cell nucleus.
One gene makes one protein.
A gene is made of DNA.
Bacteria and viruses have DNA too.
The DNA molecule is shaped like a twisted ladder.
A half DNA ladder is a template for copying the whole.
RNA is an intermediary between DNA and protein.
DNA words are three letters long.
A gene is a discrete sequence of DNA nucleotides.
The RNA message is sometimes edited.
Some viruses store genetic information in RNA.
RNA was the first genetic molecule.
Mutations are changes in genetic information.
Some types of mutations are automatically repaired.
A chromosome is a package for DNA.
Higher cells incorporate an ancient chromosome.
Some DNA does not encode protein.
Some DNA can jump.
Genes can be turned on and off.
Genes can be moved between species.
DNA responds to signals from outside the cell.
Different genes are active in different kinds of cells.
Master genes control basic body plans.
Development balances cell growth and death.
A genome is an entire set of genes.
Living things share common genes.
DNA is only the starting point for understanding human biology.
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